genomic analysis

Genome-wide binding analysis of 195 DNA-binding proteins reveals reservoir promoters and human-specific SVA family repeat region

Re-analyzed ENCODE data reveal 1,362 'reservoir' promoters with up to 111 different DNA-binding proteins present but no steady-state RNA expression.

Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers

Histone deacetylase inhibitors prefererentially suppress expression super-enhancer-driven genes, which are associated with cancer.